Read e-book online The Endometrium: Hormonal Impacts PDF
By Jean Pierre Gautray (auth.), Jean de Brux, Rodrigue Mortel, Jean Pierre Gautray (eds.)
Although the body structure of the menstrual cycle looks transparent and simply defined through a stability within the focus of assorted intercourse steroid hormones, quite a few information of its mechanism are nonetheless poorly understood and little is understood in regards to the courting between scientific occasions, plasma hormone concentrations, molecular affects on track tissues and their law. within the following chapters, the authors have tried to set up a correlation among endometrial histology and well-understood physiologic occasions of the menstrual cycle. they've got supplied updated info at the results of assorted hormones and mixtures of hormones at the endometrium. The interdependence of endometrial morphology, molecular biology, endocrinology and body structure, presents grounds for a greater knowing of the complicated mechanism of the menstrual cycle, and sheds a few gentle on its pathophysiology. Such an technique provides ariother measurement to interpretation of many menstrual abnormalities and diverse points of infertility in ladies with common physiognomies and it sounds as if common menstrual cycles. The pathologist needs to be conscious of those new suggestions given that a data of sensible alterations mirrored in hormone serum degrees and intercourse steroid receptor concentrations permits a mare particular research and a greater interpretation of the structural beneficial properties of the endometrium. this knowledge positioned within the right scientific context will help the gynecologist offer optimum remedy. The reader will discover a invaluable reference for a synthesis of medical, morphological, and biochemical info concerning the menstrual cycle and its aberrations.
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Extra resources for The Endometrium: Hormonal Impacts
In combined estrogen-progestative treatments, both elements are missing. In sequential treatment, the connective spines are barely visible; sometimes they are rare but long, forming invaginations into the lumen, whereas the normal endometrium shows a regular lacy appearance. The spiral arteries are the result of transformation of the capillaries by progesterone. They are characterized by the appearance of myofibrils in the pericytic cells, whose cytoplasm widens and increases, forming an arteriolar wall without elastic fibers (Ancla and de Brux, 1964).
1974, Cyclic changes in oviduct morphology and residual cytoplasmic estradiol binding capacity induced by sequential estradiol-progesterone treatment of spayed rhesus monkeys, Endocrinology, 95:1094. , Upchl,lrch, S. , 1978a, Heterogenity of estrogen binding sites in the cytosol of rat uterus, J. Bio1. , 253:7630. , 1979, Female sex steroids - Receptors and Functions, Springer Verlag, Berlin. , 1978b, Biology and pharmacology of estrogen receptors. W. O'~1a11ey, and L. , Vol. 2, Academic Press, New York, p.
In ovariectomized animals, a single injection of estrogens or progesterone determines cellular multiplication. If daily injections of progesterone are given after an injection of estrogens, stromal cell division is maximal on day 3 of the progesterone treatment. Moreover, if, a single dose of estrogens is injected after progesterone injection, the stromal cells undergo an increased rate of mitosis. This demonstrates that the stromal response is strongly affected by previous progesterone and estrogen treatment.
The Endometrium: Hormonal Impacts by Jean Pierre Gautray (auth.), Jean de Brux, Rodrigue Mortel, Jean Pierre Gautray (eds.)