Radovan Zak (auth.), Robert M. Dowben, Jerry W. Shay (eds.)'s Cell and Muscle Motility PDF
By Radovan Zak (auth.), Robert M. Dowben, Jerry W. Shay (eds.)
Motility is a basic estate of dwelling platforms, from the cytoplasmic streaming of unicellular organisms to the main hugely differentiated and devel oped contractile process of upper organisms, striated muscle. examine on var ious points of motile structures in muscle and undifferentiated or non muscle cells has been constructing at an ever extra fast speed within the laboratories of investiga tors with a wide selection of backgrounds utilizing methodologies various from me chanics to the main refined actual measurements. major contri butions to our realizing of motility are coming from the disciplines of telephone biology, biochemistry, pharmacology, molecular biology, biophysics, and body structure. The findings have relevance not just to easy scientists yet to clinicians in such assorted fields as cardiology and neurology and to scientists within the extra conventional actual sciences. telephone and Muscle Motility is a brand new multivolume sequence of essays through distinct study staff in a number of fields whose paintings has a standard thread of facing one element or one other of motility. The essays are supposed to concentrate on themes of present curiosity, to be serious instead of exhaustive, and to point the present developments of analysis efforts. The sequence is meant to foster an interchange of thoughts between a variety of employees within the box and to function a reference for college kids and staff who desire to familiarize themselves with the most up-tp-date growth in motility.
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Extra resources for Cell and Muscle Motility
P. , Thomas, M A. , 1979, Structural differences in the heavy chains of rat ventricular myosin isoenzymes, FEBS LETT. 97:330. , 1970, Myogenesis, in: Cell Differentiation (0. ), pp. 476-503, Van Nostrand Reinhold, New York. , Marshal, T. , 1957, An analysis of myogenesis by the use of fluorescent antimyosin, J. Biophys. Biochem. Cyto!. 3:705. , 1974, Perpective in myogcmesis, Biochimie 56: 1575. , 1972, Homologous methylated and non-methylated histidine peptides in skeletal and cardiac myosin, I Bio!.
Purified mRN A for the light chains has not been isolated, although it has been shown conclusively that myosin light chains are synthesized by a different set of smaller-size polysomes than those that synthesize heavy chains (Sarkar and Cooke, 1970). By using cDNA probes for myosin heavy-chain mRNA to analyze the levels of sequences transcribed during muscle differentiation in culture, it has been clearly shown that the transcription of myosin mRNA increases during myogenesis. Comparison of the rates of myosin synthesis with the level of myosin heavy-chain mRNA suggests, however, that not all the newly synthesized mRNA is being translated (Robbins and Heywood, 1978).
Thus, the compensatory enlargement of the hearts of young animals is achieved by cellular hypertrophy and hyperplasia. As far as changes in the isoprotein composition of the enlarged myocardium are concerned, so far only myosin has been examined in some detail. In ventricles of newborn animals, the ATPase activity of myosin is found to be substantially higher than in the adult (Syrovy, 1976). , 1978). Ventricles of young rats, for example, contain mostly the VM-l myosin isozyme, which has higher ATPase activity than the other two forms of myosin seen in the adult.
Cell and Muscle Motility by Radovan Zak (auth.), Robert M. Dowben, Jerry W. Shay (eds.)