Read e-book online Cardiac Arrhythmias: The Management of Atrial Fibrillation PDF
By P. J. Schwartz (auth.), Prof. Dr. Ronald W. F. Campbell, Prof. Dr. Michiel J. Janse (eds.)
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Extra info for Cardiac Arrhythmias: The Management of Atrial Fibrillation
The critical wavelength where atrial arrhythmias (repetitive responses or atrial flutter) started to be induced was 12 cm, and the critical wavelength for atrial fibrillation was 8 cm. Because of the variety of drugs administered, values for conduction velocity and refractory period varied widely. Atrial fibrillation could be induced over a wide range of refractory periods (50-150 ms) and conduction velocities (50-140 cm/s). For each of these parameters there is a wide overlap between the population of "no arrhythmias" and atrial fibrillation.
This consideration prompted us to investigate the effects of flecainide, propafenone and moricizine (commonly grouped into class Ic) in human ventricular heart muscle. 3 3 Frequency (Hz) Fig. 1 a, b. Effects of quinidine in human ventricular heart muscle. a Original recordings of action potential (upper traces) and force of contraction (Fo tower traces) under control conditions and in the presence of quinidine 10 Ilmol/l (Q) were superimposed. Records were obtained from two different preparations dissected from the same heart.
Jahne! et al. a 300 ::tr-- Vl ....... ,'e" I~ 0102030 100 "C ....... > "C o 3 5 B 10 30 Recovery interval 20 ~) Pulse trains at 1Hz b g Propafenone Vl ....... ,'e" 200 > "C 150 "C ....... 9 S o 20 40 60 Flecainide Moricizine ~D o 20 40 60 0 20 40 60 Time (s) Fig. 3 a, b. Determination of time constants for recovery from frequency-dependent block a Illustration of the experimental procedure for calculation of Trec ' For further details see text. b Influence of propafenone 3 I1mol/l, flecainide 3 I1mol/1 and moricizine 3 I1mol/1 on Trec in human ventricular heart musc1e.
Cardiac Arrhythmias: The Management of Atrial Fibrillation by P. J. Schwartz (auth.), Prof. Dr. Ronald W. F. Campbell, Prof. Dr. Michiel J. Janse (eds.)