Organization Name:

Department of Health and Human Services

Grant Title:

Development of Disease Biomarkers

Contact Person:

Maren R. Laughlin

Location:

6707 Democracy Blvd., Room 787
Bethesda, MD 20892-5460

Phone Number:

(301) 534-8802

Fax Number:

(301) 480-0475

Email Address:

ml33q@nih.gov

Application Deadline:

Not Applicable

Activity Type:

Health

Geographic Scope:

All U.S.

Objectives/Outcomes:

The goal of this initiative is to validate biomarkers for well-defined human diseases of liver, kidney, urological tract, digestive and hematologic systems, and endocrine and metabolic disorders, diabetes and its complications, and obesity, for which there are no or very few biomarkers, or for which standard biomarkers are currently prohibitively invasive or expensive. New biomarkers will stimulate bench to bedside translation by providing measures of the biological effects of potential new treatments. The ideal biomarker can be measured in a minimally invasive way, can be measured repeatedly over time, identifies early stages of disease, is indicative of disease prognosis, and correlates well with progression and response to therapy. Especially of interest would be studies designed to test the validity of candidate biomarkers or new technologies to monitor candidate biomarkers in patient tissue samples or small groups of well-characterized patients. For biomarkers already validated in human subjects, the larger effort might be to establish a reliable assay prior to pursuing larger patient studies. Priority will be given to those projects with high promise for improving clinical care in the relatively near future. Studies of potential biomarkers conducted in animal models of disease, and extended prospective clinical trials for marker validation against hard clinical endpoints, are outside the scope of this initiative.

Eligibility:

1. Eligible Applicants 1.A. Eligible Institutions You may submit (an) application(s) if your organization has any of the following characteristics: For-profit organizations Non-profit organizations Public or private institutions, such as universities, colleges, hospitals, and laboratories Units of State government Units of local government Eligible agencies of the Federal government Foreign Institutions Domestic Institutions Faith-based or community-based organizations 1.B. Eligible Individuals Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs